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    Uptick in Respiratory and Cardiac Problems due to Poor Air Quality grips Delhi

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    Robotic kidney surgery successfully performed on a 21-day old infant

    Robotic kidney surgery successfully performed on a 21-day old infant

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    Free medical camp held in Rohtak to honour legacy of Dr. S.N. Chugh

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    India to have more than sufficient stock of Liposomal Amphotericin B drug: Mansukh Mandaviya

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    Uptick in Respiratory and Cardiac Problems due to Poor Air Quality grips Delhi

    Uptick in Respiratory and Cardiac Problems due to Poor Air Quality grips Delhi

    Climate Change: The Hidden Catalyst of Viral Outbreaks

    Climate Change: The Hidden Catalyst of Viral Outbreaks

    Robotic kidney surgery successfully performed on a 21-day old infant

    Robotic kidney surgery successfully performed on a 21-day old infant

  • Top Stories
    Free medical camp held in Rohtak to honour legacy of Dr. S.N. Chugh

    Free medical camp held in Rohtak to honour legacy of Dr. S.N. Chugh

    Health Minister chairs a review meeting with key experts and officials on new XE-variant

    Health Min Bans 14 Fixed-Dose Combination Drugs in India

    BestDoc expands its operations to Dubai

    BestDoc expands its operations to Dubai

  • Industry Spotlight
    Mumbai Oncocare Centre raises $ 10 million in Series A funding

    2070 Health raises $30M in seed funding

    Freudenberg Medical’s Bold Leap: Embracing India’s Dynamic Healthcare Landscape

    Freudenberg Medical’s Bold Leap: Embracing India’s Dynamic Healthcare Landscape

    Metropolis Healthcare launches test for HSCT & solid organ transplantation

    Metropolis Healthcare launches test for HSCT & solid organ transplantation

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    Breast Cancer: Better safe than sorry

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    Beware gym goers: weight lifting might make your veins stick out

    Beware gym goers: weight lifting might make your veins stick out

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    Top Diet Tips for students to beat stress this exam season

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    How better planning, behaviour regulation may lead to eating less fat

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    How India is making its presence felt in the world pharmaceutical market

    How India is making its presence felt in the world pharmaceutical market

    Top Health News of the Day: July 22, 2021

    8,001 Janaushadhi Kendras opened so far covering all the districts of the country

    India to have more than sufficient stock of Liposomal Amphotericin B drug: Mansukh Mandaviya

    India to have more than sufficient stock of Liposomal Amphotericin B drug: Mansukh Mandaviya

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About 771 variants of concerns have been detected in a total of 10787 Covid positive samples

Genome Sequencing by INSACOG shows variants of concern and a Novel variant in India

March 25, 2021
Immune protection needs to be long-lasting: Dr. Dipyaman Ganguly

By Health In Five Writer

With the beginning of the INSACOG initiative, about 771 variants of concerns (VOCs) have been detected in a total of 10787 Covid positive samples shared by States/UTs. These include 736 samples positive for viruses of the UK (B.1.1.7) lineage. 34 samples were found positive for viruses of the South African (B.1.351) lineage.  1 sample was found positive for viruses of the Brazilian (P.1) lineage. The samples with these VOCs have been identified in 18 States of the country.

The Indian SARS-CoV-2 Consortium on Genomics (INSACOG) is a grouping of 10 National Laboratories that was established by Ministry of Health and Family Welfare, Govt of India on 25/12/2020. INSACOG is since then carrying out genomic sequencing and analysis of circulating COVID-19 viruses, and correlating epidemiological trends with genomic variants. Genomic variants of various viruses are a natural phenomenon and are found in almost all countries.

Genome sequencing and analysis have been carried out on samples from arriving international travelers, contacts of those positive for VOC and community samples from most of the States at INSACOG partner laboratories which are 10 in number.

The analysis of samples from Maharashtra has revealed that compared to December 2020, there has been an increase in the fraction of samples with the E484Q and L452R mutations.  Such mutations confer immune escape and increased infectivity. These mutations have been found in about 15-20% of samples and do not match any previously catalogued VOCs. These have been categorized as VOCs but require the same epidemiological and public health response of “increased testing, comprehensive tracking of close contacts, prompt isolation of positive cases & contacts as well as treatment as per National Treatment Protocol” by the States/UTs.

From Kerala 2032 samples (from all 14 districts) have been sequenced. The N440K variant that is associated with immune escape has been found in 123 samples from 11 districts. This   variant was earlier found in 33% of samples from Andhra Pradesh, and in 53 of 104 samples from Telangana. This variant has also been reported from 16 other countries including UK, Denmark, Singapore, Japan and Australia. As of now these can be at best said to be variant under investigation.

Though VOCs and a new double mutant variant have been found in India, these have not been detected in numbers sufficient to either establish or direct relationship or explain the rapid increase in cases in some States. Genomic sequencing and epidemiological studies are continuing to further analyze the situation.

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